Some chemical education researchers and chemistry textbook authors describe the abstract nature of chemistry as one of the primary causes of student difficulties. This abstractness makes it difficult to overcome chemical misconceptions. It also makes it particularly challenging for students in traditional classrooms who generally lack the in-class opportunities to make the content personally meaningful and thus more concrete. This presentation will describe flipped classroom strategies that are designed to address these dilemmas. In particular, methods of making connections between the out-of-class and in-class components of a flipped chemistry class will be emphasized. One method will be how online quizzing can be used for detecting chemical misconceptions, thus helping the teacher frame the ensuing classroom discussion. The presentation will conclude with a discussion of how the flipped chemistry model is supported by the developmental theories of both Vygotsky and Piaget.